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HPV16 E6 and E7 are required for the suppression of the innate immune response (IIR). N/Tert-1 cells (TERT immortalized foreskin keratinocytes) containing an episomal, intact HPV16 genome have an activated DDR and a repressed IIR. However, a stop codon in either E6 or E7 blocks the repression of the IIR and if the expression of both oncogenes is blocked, this significantly attenuates cell growth.
