Table 3.

Comparison of the number of platelets (PLTs) and plasma hemostatic parameters between patients with non–severe and severe coronavirus disease 2019 (COVID–19).

Parameter [Unit]	Non–Severe COVID–19	Severe COVID–19	Probability Value (Non–Severe versus Severe COVID–19)	Reference
Platelet (PLT) count [× 109/L]	149.0 (131.0–263.0) n = 28	196.0 (165.0–263.0) n = 13	0.45	[32]
	165.0 (125.0–188.0) n = 102	142.0 (119.0–202.0) n = 36	0.78	[33]
	172.0 (139.0–212.0) n = 926	137.5 (99.0–179.5) n = 173	not determined	[35]
	175.6 (148.3–194.0) n = 10	157.0 (134.0–184.5) n = 11	0.88	[44]
	181.4 ± 70.7 n = 27	186.6 ± 68.1 n = 13	not determined	[45]
	201.0 (157.0–263.0) n = 58	217.0 (154.0–301.0) n = 9	0.81	[46]
Prothrombin time; PT [s]	10.7 (9.8–12.1) n = 28	12.2 (11.2–13.4) n = 13	0.012	[32]
	12.9 (12.3–13.4) n = 102	13.2 (12.3–14.5) n = 36	0.37	[33]
	13.4 (12.8–13.7) n = 10	14.3 (13.6–14.6) n = 11	0.15	[44]
	13.1 ± 0.6 n = 27	13.4 ± 0.6 n = 13	not determined	[45]
International normalized ratio (INR)	1.0 ± 0.1 n = 27	1.0 ± 0.1 n = 13	not determined	[45]
Activated partial thromboplastin time; aPTT [s]	27.7 (24.8–34.1) n = 28	26.2 (22.5–33.9) n = 13	0.57	[32]
	31.7 (29.6–33.5) n = 102	30.4 (28.0–33.5) n = 36	0.09	[33]
	44.0 (42.6–47.6) n = 10	33.7 (32.1–38.4) n = 11	0.002	[44]
	39.5 ± 4.6 n = 27	39.5 ± 4.2 n = 13	not determined	[45]
Fibrinogen levels [g/L]	4.5 ± 1.4 n = 27	6.3 ± 1.3 n = 13	not determined	[45]
D–dimer levels [mg/L]	0.5 (0.3–0.8) n = 28	2.4 (0.6–14.4) n = 13	0.0042	[32]
	166 (101–285) n = 102	414 (191–1324) n = 36	< 0.001	[33]
	0.2 (0.1–0.3) n = 82	0.4 (0.2–2.4) n = 56	< 0.001	[38]
	0.3 (0.3–0.4) n = 10	2.6 (0.6–18.7) n = 11	0.029	[44]
	0.4 (0.2–0.8) n = 27	0.9 (0.7–1.5) n = 13	not determined	[45]
	0.3 (0.2–0.5) n = 240	0.5 (0.3–0.9) n = 58	< 0.001	[63]