Table 2.
The relationship between human papillomaviruses (HPV) and Epstein–Barr virus (EBV) status by PCR and clinicopathological variables.
| Variable | HPV (PCR) | EBV (PCR) | ||
|---|---|---|---|---|
| (−) n = 8 (%) |
(+) n = 98 (%) |
(−) n = 80 (%) |
(+) n = 26 (%) |
|
| Tumor grade | ||||
| Grade 1 | 0 (0) | 1 (1) | 1 (1) | 0 (0) |
| Grade 2 | 6 (75) | 59 (61) | 48 (61) | 17 (65) |
| Grade 3 | 2 (25) | 37 (38) | 30 (38) | 9 (35) |
| p-value | 0.72 | 0.80 | ||
| Tumor stage * | ||||
| Stage I | 1 (12) | 20 (21) | 15 (19) | 6 (23) |
| Stage II | 2 (25) | 22 (23) | 19 (24) | 5 (19) |
| Stage III | 4 (50) | 49 (51) | 40 (51) | 13 (50) |
| Stage IV | 1 (12) | 5 (5) | 4 (5) | 2 (8) |
| p-value | 0.81 | 0.83 | ||
| Sex | ||||
| Male | 4 (50) | 60 (61) | 46 (58) | 18 (69) |
| Female | 4 (50) | 38 (39) | 34 (42) | 8 (31) |
| p-value | 0.53 | 0.29 | ||
| Tumor origin | ||||
| Rectum | 0 (0) | 94 (96) | 77 (96) | 25 (96) |
| Sigmoid | 0 (0) | 2 (2) | 2 (3) | 0 (0) |
| Other parts of colon | 0 (0) | 2 (2) | 1 (1) | 1 (4) |
| p-value | 0.84 | 0.51 | ||
| HPV (+) | 25 (96) | |||
| p-value | 0.41 | |||
* The staging was according to the American Joint Committee on Cancer (AJCC) TNM system (8th edition). PCR = polymerase chain reaction; HPV = human papillomavirus; EBV = Epstein–Barr virus.