Figure 1.

HKC ameliorates kidney injury in UUO mice. (A) Representative images of H&E staining (upper two panels) and Masson’s trichrome staining (lower two panels) of kidney sections from sham and UUO mice with different treatment. Yellow arrowheads indicated the inflammatory cell infiltration of the kidney tissues. Yellow asterisks indicated the fibrotic tissues. Scale bar = 100 μm. (B) Quantification of tubulointerstiatial injury score in H & E stained sections. (C) Quantification of renal interstitial fibrosis score in Masson’s trichrome stained sections. ^## P < 0.01, UUO group vs. sham group; ^* P < 0.05, **P < 0.01, UUO + HKC or UUO + losartan group vs. UUO group. Bar graphs represent the mean ± SEM (n = 4).