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. 2020 Jul 3;11:996. doi: 10.3389/fphar.2020.00996

Figure 5.

Figure 5

Deletion of Trpc6 inhibits canonical and non-canonical TGF-β signaling pathways in UUO mice. Representative western blots and quantification of the levels of smad2 (A), smad3 (B) and phosphorylation levels of p38 (C), JNK1/2 (D), and ERK1/2 (E) in WT and TRPC6 KO mice. GAPDH was used as an internal control. ## P < 0.01, UUO group vs. sham group in each genotype; ** P < 0.01, TRPC6 KO vs. WT in UUO mice. Bar graphs represent the mean ± SEM (n = 3).