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. 2020 Jul 3;11:996. doi: 10.3389/fphar.2020.00996

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Copyright © 2020 Gu, Ge, Zhao, Wang, Zhang, Tang, Cao, Yu and Chai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory effect of HKC on TRPC3/6 activity in HEK-293 cells expressing TRPC3 or TRPC6 channels. (A) Representative traces of whole-cell currents recorded at +100 (blue traces) and −100 mV (red traces) induced by GSK1702934A (3 μM) in HEK-293 cells expressing TRPC6. (B) Current-voltage (I-V) curves induced by GSK1702934A in the presence of vehicle (Veh, 0.1% DMSO) or different concentration of HKC. (C) Concentration-response curves for HKC inhibition of TRPC6 current recorded at +100 mV. (D) Representative traces of whole-cell currents recorded at +100 (blue traces) and −100 mV (red traces) induced by GSK1702934A (3 μM) in HEK-293 cells expressing TRPC3. (E) Current-voltage (I-V) curves induced by GSK1702934A in the presence of vehicle (Veh, 0.1% DMSO) or different concentration of HKC. (F) Concentration-response curves for HKC inhibition of TRPC3 current recorded at +100 mV. Each data point represents the mean ± SEM (n = 4).