Table 3.

Associated risk factors with virological failure at the Tefera Hailu Memorial Hospital, Sekota, northeast Ethiopia, 2019

Variables	Category	COR (95% CI)	P-V	AOR (95% CI)	P-V
Age	10–19	5.78 (1.3–25.71)	0.021*	4.39 (0.2–116.5)	0.37
	20–29	1.73 (0.41–7.35)	0.45	2.87 (0.32–25.4	0.34
	30–39	1.50 (0.41–5.52)	0.54	1.12 (0.16–7.72)	0.91
	40–49	1.62 (0.43–6.08)	0.47	2.36 (0.35–15.9)	0.37
	50 +		1		1
Education status	Not read/write	1.56 (0.4–6.13)	0.52	0.97 (0.094–83.03)	0.98
	Primary	3.52 (1.0–12.43)	0.05	1.58 (0.195–12.9)	0.66
	Secondary	2.97 (0.79–11.15)	0.10	2.19 (0.26–18.5)	0.47
	Above secondary		1		1
Current ART regimen	1c	0.54 (0.13–2.28)	0.41	2.1 (0.09–48.9)	0.64
	1d	0.21 (0.05–0.91)	0.037*	0.4 (0.01–12.6)	0.60
	1e	0.16 (0.04–0.64)	0.01*	0.14 (0.003–5.6)	0.29
	1f	0.179 (0.02–1.29)	0.08	0.33 (0.007–17.2)	0.58
	4c		1		1
Baseline ART regimen	1a	0.24 (0.054–1.08)	0.06	0.29 (0.005–15.4)	0.54
	1b	0.33 (0.09–1.24)	0.10	1.13 (0.02–76.0)	0.95
	1c	0.37 (0.09–1.37)	0.136	0.39 (0.01–15.9)	0.62
	1d	0.28 (0.08–0.97)	0.046*	1.15 (0.02–65.5)	0.94
	1e	0.15 (0.04–0.50)	0.002*	1.18 (0.02–80.3)	0.94
	4c		1		1
Current CD4 result	≤ 100	36.55 (9.9–94.77)	< 0.001*	42.36 (7.43–79.6)	0.000*
	101–250	7.12 (2.33–21.8)	0.001*	12.1 (2.76–53.1)	0.001*
	251–500	3.36 (1.03–10.96)	0.045*	4.78 (1.15–19.77)	0.031*
	501 +		1
Current clinical stage	I		1		1
	II	6.79 (2.82–16.34)	< 0.001*	1.1 (0.09–13.3)	0.94
	III	6.79 (1.32–35.03)	0.022*	3.15 (0.83–12.0)	0.09
Dose of ART per day	Once	0.49 (0.25–0.95)	0.036*	0.48 (0.06–4.1)	0.50
	Twice		1
Drug interruption	No		1		1
	Yes	3.30 (1.50–7.24)	0.003*	1.19 (0.37–3.86)	0.77
Drug adherence	≥ 95%		1		1
	< 95%	9.04 (4.37–18.7)	< 0.001*	6.36 (20.35–17.2)	0.000*
Prophylaxis	No		1		1
	Yes	3.88 (10.18–12.77)	0.026*	5.42 (0.98–29.9)	0.053
TB history	Yes	1.86 (0.9–1.80)	0.09	1.53 (0.53–4.45)	0.44
	No		1		1
Immunologic failure	No		1		1
	Yes	7.63 (2.84–20.5)	0.000*	0.06 (0.003–1.5)	0.088
Duration on ART (months)	6–24	0.13 (0.02–0.97)	0.047*	0.48 (0.01–0.97)	0.048*
	25–48	0.41 (0.14–1.23)	0.11	0.37 (0.07–1.87)	.23
	49–72	0.50 (0.21–1.20)	0.122	0.24 (0.06–0.97)	0.06
	73 +		1		1

^{1a = d4T/3TC/NVP, 1b = d4T/3TC/NVP, 1c = AZT/3TC/NVP, 1d = AZT/3TC/EFV, 1f = TDF/3TC/NVP, 4c = AZT/3TC/NVP}

^{PV probability value, COR crude odds ratio, *P < 0.05, CI confidence interval, AOR adjusted odds ratio}