Fig. 5.

Exosomes relieved pain in OA rats. a PWT and PWL were used to evaluate mechanical pain sensitivity and hyperalgesia. ^$< 0.05, ^$$< 0.01, ^$$$< 0.001, compared with the baseline level before model establishment (week 0). *< 0.05, **< 0.01, ***< 0.001, compared with the sham group. ^#< 0.05, ^##< 0.01, compared with the OA group. n = 8 for each group. b Immunofluorescence staining of CGRP and iNOS protein in the dorsal root ganglion (DRG) tissue. Scale bar = 200 μm. *< 0.05, ***< 0.001, compared with the sham group. ^#< 0.05, ^###< 0.001, compared with the OA group. n = 4 for each group. c Western blot analysis of protein levels of CGRP and iNOS in the DRG tissue. ***< 0.001, compared with the sham group. ^###< 0.001, compared with the OA group. n = 4 for each group