FIGURE 6.

In vivo fluorescence of the mouse retina after curcumin tail vein injections. (A–C) In vivo longitudinal fluorescence images of an individual Tg mouse at 3, 9, and 16 months of age. (D–F) In vivo longitudinal fluorescence images of an individual WT mouse at 3, 5, and 16 months of age. The pattern of Aβ in vivo fluorescence is seen as bright green specks (white arrowheads). Note that the Aβ in vivo fluorescent deposits increased as the animal aged. Representative landmark blood vessels are labeled with orange numbers and can be identified in each of the images in the Tg (A–C) and in the WT (D–F). Dashed white circle indicates area of the optic nerve head. Representative examples of the in vivo longitudinal fluorescence images of an individual WT mouse at 3, 5, and 16 months of age reveals that Aβ fluorescent deposits only marginally increased as the animal aged (D–F). Note a significantly higher load of Aβ fluorescent deposits in the 16 month Tg (C) compared to the 16 month WT (F) mice.