Figure 1.

All BCR-ABL TKIs induce HUVEC membrane damage after 72 h. MTS (A) and LDH (B) assays were performed on HUVECs exposed for 72 h to the indicated BCR- ABL TKI in medium with 10% dialyzed FBS. Data are presented as means ± SEM of n = 9 of three independent experiments (N = 3). Results are expressed relative to control (DMSO 0.2%). Differences between conditions were tested using the Wilcoxon signed rank test that compared the effect of each TKI condition versus control. *p < 0.05 and **p < 0.01.