Figure 5.

Dasatinib and bosutinib reduce wound closure. HUVEC migration was assessed by a scratch test after exposure of the cells to BCR-ABL TKIs for 24 h in 10% FBS media to avoid cell death due to serum-free conditions. Histograms represent wound closure 6 h after the scratch. Bars represent the means ± SEM of n = 6 of three independent experiments (N = 3). Differences between conditions were tested using the Wilcoxon signed rank test that compared each TKI condition versus control. *p < 0.05.