Figure 6.

BCR-ABL TKIs do not increase adhesion molecule expression on HUVECs. Expression of ICAM-1 (A), VCAM-1 (B), and E-selectin and P-selectin (C) by HUVECs after a 4-h activation by 10 ng/ml of TNF-α followed by a 24 h treatment with BCR-ABL TKI in medium without FBS. Data are presented as means of the absorbance ± SEM of n = 9 of three independent experiments (N = 3). Three concentrations were tested for each TKI. Results are expressed relative to control (DMSO 0.2%). Differences between conditions were tested using the Wilcoxon signed rank test. *p < 0.05 and **p < 0.01.