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. 2020 Jul 3;8:758. doi: 10.3389/fbioe.2020.00758

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Copyright © 2020 Thakur, Hebbi, Parida and Rathore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profiles of continuous operation with (A) turbidity-based switching for HP PDH4 (Sample: HSA Pichia pastoris broth with 5% solids on wet weight basis), and (B) pressure-based switching for X0HC (Sample: mAb CHO cell culture centrate).