FIGURE 2.

Platelets, leukocytes, and EV expression of PS and TF: Data documented as mean ± SEM. Symbol designation denoted significant difference from static control labeled as x, o, and # for low, nominal, and high flow rates, respectively. Significant differences between flow rates are denoted on the graph with a * and corresponding z-bar. A, Platelet expression of phosphatidylserine with significant differences between samples from circuits compared to static control. B, Platelet extracellular vesicles (PEVs) for circuits and static control. C, STA-Procoagulant Phospholipid Clot Time® (PPL) with significant differences from static control at 1, 2, and 4 h for all flow rates. D, Leukocyte expression of tissue factor with significant differences from static control and the 0.3-L/min to 0.7-L/min flow rates. E, Leukocyte EV with significant differences between 0.5-L/min flow rate and 0.3-L/min and 0.7 L/min flow rates. F, Tumor necrosis alpha (TNF-α) with significant differences after 2 h in the 0.3-L/min and 0.7-L/min flow rates and the 0.5- L/min flow rate and the static control. EV, extracellular vesicle; PS, phosphatidylserine; SEM, standard error of the mean; TF, tissue factor