Figure 5.

IS overload increased cognitive impairment and BBB disruption in 0.5% ARD rats. Evaluation of ARD rats with IS overload compared with control or 0.5% ARD rats. (A) Serum indoxyl levels at D28. (B) Relative AhR activation by the rats’ serum (by percentage of FICZ) at D28. (C) Discrimination index of the NOR test. (D) Brain content of 99mTc-DTPA cerebral scintigraphy in percentage of injected activity by gram of brain (% IA/g). (E) IS levels in CSF. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001.