Table 3.
General additive mixed model analysis of GFR mean and SD in three population-based cohorts
| Variable | β (95% CI) | P Value |
|---|---|---|
| Effect of independent variables on mean GFR | ||
| 50-year-old female who was unhealthy (intercept) | 98.91 (97.43 to 100.39) | <0.001 |
| Age, per yr | −1.22 (−1.43 to −1.02) | <0.001 |
| Healthy (yes/no)a | −3.25 (−4.86 to −1.63) | <0.001 |
| Male sex | −0.82 (−8.54 to 6.90) | 0.84 |
| Interaction between age and being healthya | 0.30 (0.18 to 0.43) | <0.001 |
| Interaction between age and male sex | 0.20 (0.06 to 0.34) | 0.005 |
| Effect of independent variables on the SD of GFR | ||
| 50-year-old female who was unhealthy (intercept) | 12.40 (10.53 to 14.61) | <0.001 |
| Percentage change associated with each independent variable | ||
| Age, per yr | −0.1% (−0.6% to 0.3%) | 0.52 |
| Healthy (yes/no)a | −18.6% (−23.9% to −13.0%) | <0.001 |
| Male sex | 1.4% (−3.5% to 6.6%) | 0.59 |
GFR measured in ml/min per 1.73 m2. Model adjusted for random cohort effects and for random intercepts for each participant, see Supplemental Table 3 for random effect results. Fixed effects of health status, age, and sex.
a
Healthy was defined as no cardiovascular disease, cancer, diabetes, hypertension, smoking, lipid-lowering medication, or digoxin, as well as body mass index <30 kg m−2 and urinary ACR <30 mg/g.