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. 2020 Jun 2;31(7):1539–1554. doi: 10.1681/ASN.2019101100

Figure 1.

Figure 1.

miR-204-5p is downregulated in kidneys of patients with hypertension, hypertensive nephrosclerosis, or diabetic nephropathy. miR-204-5p abundance was measured in human kidney biopsy specimens using quantitative PCR or detected using ISH. (A) Renal miR-204-5p abundance in hypertension and hypertensive nephrosclerosis. n=10 for control, n=8 for hypertension, and n=32 for hypertensive nephrosclerosis. *P<0.05, versus control, one-way ANOVA followed by Holm–Šidák post hoc test. (B) Renal miR-204-5p abundance in diabetic nephropathy. n=7 for control and n=10 for diabetic nephropathy. *P<0.05, versus control, t test. (C) Representative ISH images in kidney biopsy from a control subject. Zoomed-in images with miR-204-5p probe show miR-204-5p expression in a glomerulus and tubules. Scale bar, 100 μm.