Figure 4.

Structure of truncated human apo A-I (pdb code 1av1) revealed several accessible sites for post-translational modifications by 4-HNE. Four molecules are associated with their hydrophobic faces to form an antiparallel four-helix bundle. (A) Lysine and histidine residues possibly modified by HNE are colored in cyan with CPK representation. (B) Model of HDL:phospholipids (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) are colored in yellow and cholesterol in magenta. Lysine and histidine residues possibly modified by HNE are colored in cyan with CPK coloring representation (pdb code 3k2s).