Figure 5.

HDL from patients on PD and HD exhibited impaired antiaggregant properties. (A) Regarding levels of TxB2, HD and PD HDL triggered overactivation of platelets compared with control HDL (n=15 for control, n=25 for HD group, and n=20 for PD group). (B) The same observations were found for healthy volunteers’ HDL modified by an incubation overnight with HNE (HNE HDL, n=5 for each group). (C) HD, PD, and HNE HDL exhibited blunted antiaggregant properties compared with control HDL (n=9 for control and HD groups, n=5 for HNE group). (D) We found a threshold effect of HNE modification on HDL because only a 100 µM solution of HNE permitted the significant alteration of the antiaggregant properties of control HDL (n=4 for each group). *P<0.05, Mann–Whitney test and Kruskal–Wallis test (in D). Data are expressed as median and interquartile range.