Table 1.

General characteristics of sham-operated (control) and 5/6 nephrectomized rabbits

Characteristics	Control (N=9)	CKD (N=8)	P Value
Biometry
Body weight (kg)	3.5 (3.2–3.9)	3.1 (3.0–3.3)	0.04
Body weight gain (kg)	1.0 (0.9–1.2)	0.7 (0.6–0.8)	0.001
Kidney weight (g)	19 (16–22)	14 (12–16)	0.008
Kidney weight (g/kg body wt)	5 (4–7)	5 (4–5)	0.21
Biologic features
Urea (mmol/L)	6.8 (5.6–8.4)	12.8 (12.6–19.2)	<0.001
Creatinine (µmol/L)	57 (52–75)	193 (154–270)	<0.001
Bicarbonate (mmol/L)	20.1 (16.8–24.0)	21.0 (14.6–22.7)	0.70
Glucose (mmol/L)	5.6 (4.8–6.9)	7.4 (7.1–8.1)	0.04
Total cholesterol (mg/dl)	47 (37–68)	109 (73–198)	<0.001
HDL cholesterol (mg/dl)	29 (18–37)	56 (35–85)	0.04
HDL-C/TC ratio	0.66 (0.33–0.85)	0.49 (0.35–0.53)	0.27
Triacylglycerols (mg/dl)	270 (228–677)	316 (165–719)	0.84
Protidemia (g/L)	59 (48–69)	39 (32–49)	0.02
Proteinuria (g/mmol creatinine)	617 (60–1287)	19 (9–56)	0.20
Iohexol clearance
GFR (ml/min per kg)	4.3 (4.1–4.8)	2.2 (1.8–2.5)	0.008
Oxidative stress markers (plasma)
MDA (µmol/L)	0.8 (0.5–1.2)	2.3 (1.2–3.0)	0.009
AOA (mmol/L)	1.0 (0.8–1.1)	0.8 (0.7–0.9)	0.02

Data are expressed as median (interquartile range). P<0.05 was considered as significant by Mann–Whitney test. Creatinine, ×0.011 for mg/dl; urea, ×2.8 for mg/dl. HDL-C, HDL cholesterol; TC, total cholesterol.