Table 3.

List of HNE-adducted amino acids in HDL constitutive proteins from patients on HD

Protein Name	Protein Label	%a	Site of Adduction	Abundance Ratio (HD 1–9, respectively)b
apo B100	APOB	0.04	K3689	0.293	0.825	0.468	4.099	8.148	1.488	1.626	3.606	0.322
			K4498	—	—	—	—	4.421	—	—	2.339	—
Serum albumin	ALB	1.15	H152	2.646	5.05	0.373	—	0.036	0.072	1.263	0.874	6.837
			K160 or H152	2.956	6.049	0.229	—	0.295	—	0.718	0.405	12.994
			K347	—	1.452	—	0.879	—	0.582	1.767	2.442	1.966
			H170	1.463	—	—	0.919	—	0.178	0.957	—	—
			K581	0.861	1.148	—	—	—	—	0.668	1.944	2.204
			K198	1.715	—	—	—	—	2.864	—	—	1.28
apo A1	APOA1	4.50	H20	0.516	0.863	1.131	2.298	1.414	1.284	1.133	1.109	0.556
			H179	2.448	2.756	5.133	1.117	0.995	1.306	0.316	0.802	0.853
			H186	2.646	2.508	4.401	0.613	0.806	0.93	0.168	1.221	1.767
			H223	0.456	0.549	1.471	0.101	0.125	0.188	—	0.136	—
			H217	1.342	0.939	3.216	0.039	0.175	0.266	—	0.14	—
			K36	0.89	1.362	1.181	1.64	0.996	1.36	1.873	1.863	1.128
			K250	1.423	3.189	0.548	4.329	31.087	1.035	3.154	30.549	2.522
			K130	0.332	1.236	0.856	—	—	—	1.018	—	0.728
			K47	0.596	1.345	1.237	2.083	0.861	1.211	2.596	2.217	1.557
			K83	0.393	—	0.943	1.004	0.559	0.79	2.181	2.642	2.131
			K64	0.571	1.139	1.079	1.643	1.119	1.543	1.403	1.616	0.935
			K262	—	10.052	—	0.757	7.534	—	0.442	42.042	—
apo(a)	LPA	0.02	K215	—	100	—	—	—	—	—	100	—
apo A2	APOA2	1	K26	—	1.983	—	0.134	—	—	0.963	0.29	0.689
Keratin, type I, cytoskeletal 10	KRT10	0.17	K362	2.598	3.076	3.419	1.44	0.596	1.462	0.778	2.66	1.595
Trypsin-3	PRSS3	0.32	H153	1.292	0.7	1.056	1.332	0.827	5.646	0.972	0.914	0.906
UDP-glucose:glycoprotein	UGGT2	0.06	H1388	1.46	1.385	3.62	3.525	4.433	2.838	5.1	11.999	1.877
glucosyltransferase 2

K, lysine; —, not found; H, histidine; UDP, uridine diphosphate.

^aPercentage of potential sites of adduction regarding all of the amino acids of the protein sequence.

^bAbundance ratio was calculated against the mean of the nine controls.