Table 1.
The comparison of the different high circulating FGF-23 models
| Model (genetic background) | Circulating FGF-23 (model:control)a | Blood-Related Parameters | Cardiac Changes | Reference |
|---|---|---|---|---|
| 80 μg/kg per d FGF-23 IOCV for 5 d (C57BL/6J) | (c + i) FGF-23 ↑ (3.2:1) | / | LVH | 33 |
| Klotho heterozygous (/) | (c + i) FGF-23 ↑ (3.0:1) | Phosphate ↑ | LVH | 33 |
| Active VitD3 ↑ | ||||
| 5/6 nephrectomy (Sprague Dawley) | (c + i) FGF-23 ↑ (12.5:1) | Creatinine ↑ | LVH | 33 |
| CCreatinine ↓ | ||||
| BUN ↑ | ||||
| Systolic pressure ↑ | ||||
| 5/6 nephrectomy (Sprague Dawley) | (c + i) FGF-23 ↑ (3.5:1) | Creatinine ↑ | LVH | 37 |
| CCreatinine ↓ | ||||
| BUN ↑ | ||||
| Systolic pressure ↑ | ||||
| Diastolic pressure ↑ | ||||
| Phosphate → | ||||
| 2.0% phosphate diet for 12 wk (C57BL/6) | (c + i) FGF-23 ↑ (6.0:1) | BUN → | LVH | 37 |
| 75 μg/kg per d FGF-23 IP for 5 d (C57BL/6) | FGF-23 ↑ (/) | Systolic pressure ↑ | LVH | 42 |
| 2.0% phosphate diet for 3 mo (C57BL/6) | iFGF-23 ↑ (5.6:1) | / | LVH | 121 |
| 5/6 nephrectomy (Sprague Dawley) | iFGF-23 ↑ (/) | CCreatinine ↓ | LVH | 121 |
| BUN ↑ | ||||
| Systolic pressure ↑ | ||||
| Diastolic pressure ↑ | ||||
| Phosphate ↑ | ||||
| PhexC733R (C3Heb/FeJ) | iFGF-23 ↑ (12.8:1) | Phosphate ↓ | No changes | 45 |
| Calcium → | ||||
| sKlotho ↓ | ||||
| Active VitD3 ↓ | ||||
| PTH ↑ | ||||
| BUN → | ||||
| Creatinine → | ||||
| Systolic pressure ↓ | ||||
| Cholesterol → | ||||
| Hyp (C57BL/6J) | / | Systolic pressure → | Smaller heart | 47 |
| Hyp (C57BL/6) | iFGF-23 ↑ (14.4:1) | Aldosterone ↓ | LVH | 50 |
| Transgenic human FGF-23 in liver (C57BL/6J) | / | Systolic pressure ↓ | LVH | 51 |
| Phosphate ↓ | ||||
| Epinephrine ↑ | ||||
| Norepinephrine ↑ | ||||
| Dopamine ↑ | ||||
| Ang-II ↑ | ||||
| Cortisol ↑ | ||||
| Glucose ↓ |
IOCV, injection of caudal vein; (c + i) FGF-23, C-terminal and intact FGF-23; /, not mentioned; VitD3, vitamin D3; CCreatinine, creatinine clearance; →, no significant difference between model group and control group; IP, intraperitoneal injection; PTH, parathyroid hormone; Hyp, X-linked semidominant mutation of Phex gene that causes hypophosphatemia and high circulating FGF-23, whereas does not affect kidney functions.
a
Model:control is calculated by average value of each group.