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. Author manuscript; available in PMC: 2020 Jul 28.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2020 Jan 3;84:95–104. doi: 10.1101/sqb.2019.84.039206

Figure 7. The niche at the site of protein synthesis affects peri-translational protein complex formation.

Figure 7.

(A) Translation of an mRNA (light green) without 3′UTR may result in the lack of an RNA granule at the site of translation and may prevent co-translational protein complex assembly. The ribosome is shown in grey and the newly synthesized protein is shown in dark green. (B) As in (A), but the presence of a local RNA granule (yellow) allows a specific protein-protein interaction between a 3′UTR-recruited protein (dark blue) and the newly synthesized protein (dark green). (C) As in (B), but a different type of RNA granule (purple) allows the formation of a different 3′UTR-dependent protein complex. (D) Translation of two different mRNAs (light red, light blue) within a larger RNA granule (grey) containing a diversity of mRNAs may allow co-or peri-translational protein complex formation.