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. Author manuscript; available in PMC: 2020 Jul 10.
Published in final edited form as: Evol Hum Behav. 2019 May 18;40(5):420–426. doi: 10.1016/j.evolhumbehav.2019.05.003

Fig. 1.

Fig. 1.

Variations in genomic imprinting on chromosome 15q11–13. Typically developing individuals express a balanced maternally- and paternally-expressed contribution. Prader-Willi syndrome (PWS) is characterized by an overexpression of maternally-expressed alleles. Angelman syndrome (AS) is characterized by an overexpression of paternally-expressed alleles in the same region. There are multiple molecular mechanisms by which these errors occur; schematic represents imbalanced imprinted contribution. Black = unimprinted genes; blue = paternally-expressed genes; pink = maternally-expressed genes; grey = unexpressed alleles; circles = imprinting centers.