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. 2020 Jul 15;439:125–136. doi: 10.1016/j.neuroscience.2019.07.036

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Gephyrin at the nanoscale level. (A) Wide-field (left) and photoactivated localization microscopy (PALM, right) of the same dendritic portion of a hippocampal neuron expressing gephyrin-mEos3.2 and immunoprobed for vGAT to localize inhibitory synapse (arrowheads). vGAT immunoreactivity is not shown on the right. Scale bar 1 μm. (B) Nanoscale organization of synaptic gephyrin in single-spot (Gaussian, left) and multi-spot (nano-domains, right) clusters. Scale bar, 100 nm. (C) Top, Schematized examples of Gaussian and nano-domains organization of the inhibitory postsynaptic disk. Bottom, During iLTP, the fraction of synapses exhibiting gephyrin nano-domains is increased. (D) Impact of synapse nanofragmentation during iLTP on simulated IPSC variability. [Modified from Pennacchietti et al., 2017].