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. 2020 Jul 10;15(7):e0235705. doi: 10.1371/journal.pone.0235705

Fig 5. SP-2577 promotes PD-L1 expression and rescues checkpoint inhibition sensitivity in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.

Fig 5

(A) RT-PCR analysis of COV434 pIND 20 BRG1-2.7 cells after SP-2577 treatment shows increase of PD-L1 expression levels, which are lost after doxycycline treatment. (B) Co-treatment of COV434 pIND 20 BRG1-2.7 organoids with SP-2577 and anti-PD-L1 antibodies or lymphocytes treated with anti-CTLA-4 antibodies showed an increase in lymphocyte infiltration as checked after 48 h.