Fig 9. Allowing a real-valued pathway length parameter, n, increases the gamma model’s ability to recapitulate dynamics from arbitrary linear pathways.

(A) The optimised cost values for the fixed-rate and the gamma models when they are both optimised towards the same data sets in which the pathway receives an impulse input (Table 1, 5000 data sets). The colour of the dots indicate the length of the linear pathway that was used to generate the synthetic data set. (B) Demonstrating the model performances for the median data set, as denoted by a green dot in (A). (C, D) similar to (A) and (B) but using the generalised gamma model (Eq 12) and a noisy input (Table 1).