Table 4.
Effect decomposition of the influence of psoriasis and potential mediators on adverse pregnancy outcomes in 3 million live births in the state of California
| Mediator | Total effecta | Direct effectb | Indirect effectc | Proportion mediatedd | |||
|---|---|---|---|---|---|---|---|
| aRR | 95%CI | aRR | 95%CI | aRR | 95%CI | ||
| Preterm birth | |||||||
| Preeclampsia/hypertension* | 1.46 | (1.22, 1.76) | 1.31 | (1.08, 1.58) | 1.11 | (1.05, 1.18) | 32.9% |
| Gestational diabetes | 1.48 | (1.25, 1.78) | 1.44 | (1.19, 1.74) | 1.03 | (1.00, 1.06) | 8.9% |
| Infection in pregnancy* | 1.49 | (1.25, 1.79) | 1.41 | (1.18, 1.70) | 1.06 | (1.01, 1.11) | 15.9% |
| Cesarean Delivery | |||||||
| Preeclampsia/hypertension | 1.22 | (1.11, 1.33) | 1.19 | (1.09, 1.31) | 1.02 | (1.01, 1.03) | 11.8% |
| Gestational diabetes | 1.22 | (1.12, 1.34) | 1.21 | (1.10, 1.32) | 1.01 | (1.01, 1.02) | 7.3% |
| Infection in pregnancy | 1.22 | (1.12, 1.34) | 1.22 | (1.12, 1.33) | 1.01 | (1.00, 1.01) | 3.3% |
| Small for Gestational Agee | |||||||
Models adjusted for race/ethnicity, maternal age, insurance provider, maternal education, overweight/obesity, and smoking
Effect of psoriasis on adverse pregnancy outcomes
Effect of psoriasis on adverse pregnancy outcomes that is not mediated by each pregnancy complication
Effect of psoriasis on adverse pregnancy outcomes mediated by each pregnancy complication
Proportion of effect of psoriasis on adverse pregnancy outcomes mediated by each pregnancy complication
Total effects observed between psoriasis and small for gestational age were null (aRR 1.00, 95% CI 0.81, 1.24); no mediation analysis performed
modeled with interaction term between exposure and mediator