TABLE 3.
Adverse Eventsa
| Placebo | HGH | All | |
|---|---|---|---|
| Any adverse event | 7 (78) | 8 (80) | 15 (79) |
| Back pain | 4 (44) | 5 (50) | 9 (47) |
| Constipation | 0 (0) | 1 (10) | 1 (5) |
| Elevated alanine aminotransferase | 3 (33) | 2 (20) | 5 (26) |
| Elevated aspartate aminotransferase | 3 (33) | 2 (20) | 5 (26) |
| Elevated blood glucose | 1 (11) | 0 (0) | 1 (5) |
| Fatigue | 4 (44) | 4 (40) | 8 (42) |
| Headache | 3 (33) | 3 (30) | 6 (32) |
| Increased sweating | 2 (22) | 3 (30) | 5 (26) |
| Injection site bruising | 1 (11) | 0 (0) | 1 (5) |
| Insomnia | 0 (0) | 1 (10) | 1 (5) |
| Joint pain (other than surgical knee) | 2 (22) | 3 (30) | 5 (26) |
| Joint swelling (other than surgical knee) | 0 (0) | 1 (10) | 1 (5) |
| Muscle pain (other than surgical knee) | 1 (11) | 2 (20) | 3 (16) |
| Muscle spasms/cramps | 0 (0) | 1 (10) | 1 (5) |
| Reduced appetite | 0 (0) | 1 (10) | 1 (5) |
| Stiffness (other than surgical knee) | 0 (0) | 3 (30) | 3 (16) |
| Temperature sensation fluctuations | 0 (0) | 1 (10) | 1 (5) |
| Tingling sensation/numbness | 1 (11) | 2 (20) | 3 (16) |
a
Values are presented as n (%). Differences between the placebo and HGH groups were tested with the Fisher exact test. No significant differences between groups were observed. HGH, human growth hormone.