Table 1. Gene enrichment analysis of tendons within a species.
P-values of select differentially regulated pathways from mouse and rat Achilles, forepaw digit flexors, patellar, and supraspinatus (SSP) tendons that were identified using Ingenuity Pathway Analysis.
| Pathway or Cellular Process | Achilles vs Flexor | Achilles vs Patellar | Achilles vs SSP | Flexor vs Patellar | Flexor vs SSP | Patellar vs SSP |
|---|---|---|---|---|---|---|
| Mouse | ||||||
| Actin Cytoskeleton Signaling | 1.26E-03 | 6.31E-12 | 4.07E-10 | 2.51E-14 | 9.33E-06 | 1.32E-09 |
| AMPK Signaling | 2.09E-08 | 7.41E-08 | 1.29E-07 | 2.00E-11 | 3.02E-06 | 1.12E-08 |
| Axonal Guidance Signaling | 3.31E-10 | 8.91E-09 | 2.51E-22 | 7.94E-17 | 5.01E-15 | 7.94E-16 |
| BMP signaling pathway | 4.27E-06 | 1.74E-02 | 1.95E-08 | 1.91E-07 | 4.90E-06 | 1.26E-05 |
| Calcium Signaling | 4.57E-07 | 3.98E-13 | 3.47E-10 | 8.32E-06 | 1.05E-06 | 4.47E-09 |
| Epithelial Adherens Junction Signaling | 4.27E-09 | 7.41E-08 | 1.00E-14 | 1.05E-10 | 5.89E-06 | 1.15E-08 |
| ERK/MAPK Signaling | 4.90E-07 | 3.98E-06 | 5.62E-06 | 2.51E-11 | 5.13E-09 | 7.94E-08 |
| Fatty Acid β-oxidation I | 2.45E-05 | 1.32E-02 | ND | ND | ND | ND |
| IGF-1 Signaling | 3.72E-04 | 3.72E-03 | 1.29E-03 | 2.19E-08 | 1.00E-05 | 3.02E-04 |
| ILK Signaling | 1.55E-05 | 6.31E-12 | 1.26E-09 | 1.58E-15 | 5.62E-08 | 5.50E-10 |
| Inhibition of MMPs | ND | ND | ND | ND | ND | ND |
| p70S6K Signaling | 1.02E-04 | 6.92E-03 | 9.12E-05 | 1.91E-07 | 5.25E-05 | 9.33E-05 |
| PPARα/RXRα Activation | 1.35E-08 | 1.66E-03 | 9.77E-10 | 1.48E-08 | 1.12E-07 | 2.45E-09 |
| Protein Kinase A Signaling | 9.33E-08 | 2.63E-08 | 1.58E-16 | 4.37E-09 | 6.31E-15 | 5.01E-13 |
| STAT3 Pathway | 4.68E-06 | 5.01E-03 | 3.98E-06 | 1.58E-05 | 7.76E-07 | 1.82E-06 |
| TGFβ Signaling | 4.17E-09 | 3.89E-04 | 3.89E-10 | 2.14E-07 | 7.59E-05 | 4.79E-06 |
| Tight Junction Signaling | 2.95E-05 | 6.03E-06 | 3.47E-08 | 6.61E-07 | 8.32E-05 | 2.34E-05 |
| Wnt/β-catenin Signaling | 1.91E-09 | 2.63E-04 | 4.27E-08 | 2.45E-06 | 8.91E-06 | 7.76E-04 |
| Rat | ||||||
| Actin Cytoskeleton Signaling | 6.03E-06 | 7.59E-03 | 1.32E-03 | 7.08E-06 | 7.24E-04 | 1.07E-08 |
| AMPK Signaling | 3.72E-07 | ND | 9.12E-05 | 2.69E-09 | 1.32E-06 | 4.90E-06 |
| Axonal Guidance Signaling | 1.26E-17 | 7.41E-07 | 3.24E-07 | 2.00E-21 | 1.00E-18 | 1.00E-11 |
| BMP signaling pathway | 7.94E-06 | ND | ND | 5.37E-06 | 6.92E-10 | 1.32E-04 |
| Calcium Signaling | 6.17E-04 | 1.62E-03 | 6.92E-05 | 2.82E-04 | 1.95E-03 | 6.92E-07 |
| Epithelial Adherens Junction Signaling | 9.55E-08 | ND | 7.08E-05 | 6.46E-08 | 9.33E-05 | 1.26E-09 |
| ERK/MAPK Signaling | 5.37E-07 | ND | 6.31E-03 | 3.98E-07 | 1.86E-04 | 3.72E-04 |
| Fatty Acid β-oxidation I | ND | ND | 2.95E-04 | 5.62E-03 | 2.51E-05 | 4.37E-04 |
| IGF-1 Signaling | 6.46E-04 | ND | 1.62E-02 | 1.29E-04 | 2.51E-06 | 9.77E-05 |
| ILK Signaling | 6.17E-08 | 2.19E-02 | 1.02E-03 | 1.23E-05 | 1.82E-05 | 2.75E-04 |
| Inhibition of MMPs | 4.68E-03 | 1.02E-07 | ND | ND | 3.09E-02 | 3.31E-02 |
| p70S6K Signaling | 5.62E-04 | ND | ND | 4.47E-05 | 6.31E-06 | 2.51E-05 |
| PPARα/RXRα Activation | 3.16E-05 | ND | 2.69E-03 | 4.90E-06 | 2.40E-08 | 9.12E-07 |
| Protein Kinase A Signaling | 1.26E-13 | ND | 8.51E-07 | 3.89E-09 | 1.55E-08 | 8.51E-08 |
| STAT3 Pathway | 3.72E-07 | ND | 4.68E-05 | 2.34E-10 | 4.68E-09 | 9.77E-08 |
| TGFβ Signaling | 1.29E-04 | ND | ND | 4.57E-05 | 2.04E-07 | 7.08E-05 |
| Tight Junction Signaling | 4.90E-07 | 2.82E-02 | 4.57E-02 | 1.07E-04 | 2.34E-02 | 1.70E-02 |
| Wnt/β-catenin Signaling | 7.94E-11 | ND | 4.90E-03 | 1.82E-08 | 7.94E-12 | 2.00E-05 |
ND, not significantly different.