Table 2. Gene enrichment analysis of tendons across a species.
P-values of select differentially regulated pathways from mouse and rat Achilles, forepaw digit flexors, patellar, and supraspinatus (SSP) tendons that were identified using Ingenuity Pathway Analysis.
| Pathway or Cellular Process | Mouse vs Rat Achilles | Mouse vs Rat Flexor | Mouse vs Rat Patellar | Mouse vs Rat Flexor |
|---|---|---|---|---|
| Actin Cytoskeleton Signaling | 7.59E-09 | 6.03E-04 | 8.71E-10 | 3.80E-07 |
| AMPK Signaling | 2.09E-08 | 3.09E-05 | 1.95E-09 | 1.95E-06 |
| Axonal Guidance Signaling | 1.26E-12 | 2.09E-09 | 1.58E-16 | 3.98E-14 |
| BMP signaling pathway | 3.80E-02 | 5.25E-05 | 8.13E-03 | 8.91E-06 |
| Calcium Signaling | 3.72E-05 | 5.25E-03 | 3.31E-03 | 2.82E-03 |
| Epithelial Adherens Junction Signaling | 2.24E-05 | 2.29E-03 | 4.47E-06 | 4.79E-08 |
| ERK/MAPK Signaling | 4.27E-04 | 2.19E-04 | 1.91E-06 | 2.69E-05 |
| Fatty Acid β-oxidation I | 3.72E-02 | ND | ND | 1.41E-02 |
| IGF-1 Signaling | ND | 3.02E-04 | 3.80E-06 | 3.89E-04 |
| ILK Signaling | 8.71E-07 | 2.63E-04 | 5.01E-07 | 2.14E-06 |
| Inhibition of MMPs | 6.61E-04 | 3.55E-02 | ND | 2.45E-02 |
| p70S6K Signaling | 3.80E-03 | 1.55E-04 | 8.13E-06 | 2.45E-04 |
| PPARα/RXRα Activation | 2.40E-02 | 7.08E-03 | 2.34E-05 | 2.19E-03 |
| Protein Kinase A Signaling | 4.27E-09 | 1.78E-07 | 1.26E-09 | 1.10E-05 |
| STAT3 Pathway | 3.98E-04 | 4.57E-08 | 5.75E-06 | 7.24E-05 |
| TGFβ Signaling | ND | 6.61E-04 | 3.09E-03 | 2.00E-06 |
| Tight Junction Signaling | 2.14E-03 | 2.04E-05 | 8.32E-05 | 2.63E-06 |
| Wnt/β-catenin Signaling | 1.78E-02 | 7.08E-04 | 3.80E-03 | 7.59E-05 |
ND, not significantly different.