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. 2020 Jul 10;15(4):258–264. doi: 10.1016/j.jtumed.2020.06.005

Table 2.

Studies that reported cases of genetic diversities and mutations in SARS-CoV-2.

Citation Country Experimental design Mutations Key Findings
Tang et al.13 China Population genetic analyses of 103 SARS-CoV-2 genomes Receptor-binding domain of the S protein L and S lineages discovered. L lineage was more prevalent than the S lineage. L lineage was evolutionarily aggressive and contagious compared to S lineage
Angelettie et al.12 Italy Fast-unconstrained Bayesian approximation and Homology modelling NSP2 and NSP3 a. NSP2 mutation could explain why SARS-CoV-2 is more contagious than SARS-CoV-1
b. NSP3 mutation could explain the difference in pathogenicity between SARS-CoV-2 and SARS-CoV-1
Yao et al.18 China Functional characterisation of 11 patient-derived viral isolates Intrapersonal variation and 6 different mutations in S protein S protein mutation capable of substantially changing its pathogenicity
Xi et al.19 China Phylogenetic analysis and heat mapping of 788 confirmed patients with COVID-19 Furin cleavage site mutation on S protein FCS mutation may represent an important SARS-CoV-2 evolution site
Holland et al.26 USA Genomic characterisation of a 27 amino acid in frame deletion in accessory protein ORF7a An 81-nucleotide deletion in SARS-CoV-2 ORF7a Phylogenetically distinct mutants that indicate independent transmissions pattern
Korber et al.26 USA Phylogenetic analysis of S protein D614G mutation in S protein Significant implications for SARS-CoV-2 transmission, pathogenesis, and immune interventions
van Dorp et al.27 UK Curation of dataset of 7666 public genome and genomic diversity analysis Nsp6, Nsp11, Nsp13, Spike protein Possible ongoing adaptation events of SARS-CoV-2
Pachetti et al.39 Italy 220 genomic sequences analysis from database derived from patients with COVID-19 8 novel recurrent mutations of SARS-CoV-2 RdRp
  • a.

    Findings suggest SARS-CoV-2 evaluation and co-existence in European, North American, and Asian strains

  • b.

    RdRp mutation could be involved in antiviral drug-resistance
Happi et al.40 Nigeria Genome annotation and Mutation Analysis D614G in S protein D614G mutation in S protein could be associated with higher transmission and pathogenicity and evasion of immune interventions