Table 3.
The characteristics of included studies on IL-6 gene polymorphism and pneumonia.
| First author, Year | Age group | Country | Ethnicity | Sample size (cases/controls) | Genotype (wtwt/wtmt/mtmt) |
p value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | |||||||
| −174G/C [rs1800795] | ||||||||
| Endeman, 2011 | Adult | The Netherlands | Caucasian | 200/311 | 83/92/25 | 113/150/48 | 0.878 | 8 |
| Mao, 2016 | Adult | China | Asian | 162/200 | 68/46/48 | 97/66/37 | 0.000 | 8 |
| Martinez-Ocana, 2013 | Adult | Mexico | Caucasian | 65/46 | 53/12/0 | 39/7/0 | 0.576 | 8 |
| Martın-Loeches, 2012 | Adult | Spain | Caucasian | 953/1246 | 581/516/130 | 438/413/102 | 0.752 | 8 |
| Salnikova, 2013 [a] | Adult | Russia | Caucasian | 334/141 | 37/80/22 | 103/150/69 | 0.299 | 8 |
| Salnikova, 2013 [b] | Adult | Russia | Caucasian | 216/105 | 32/56/12 | 83/81/42 | 0.009 | 8 |
| Schaaf, 2005 | Adult | Germany | Caucasian | 100/50 | 29/51/20 | 17/25/8 | 0.812 | 8 |
| Sole-Violan, 2010 | Adult | Spain | Caucasian | 1413/1162 | 533/485/120 | 590/502/123 | 0.288 | 8 |
| Zhao, 2017 | Pediatric | China | Asian | 415/300 | 391/24/0 | 296/4/0 | 0.907 | 8 |
| Zidan, 2014 | Pediatric | Egypt | African | 100/110 | 32/55/13 | 22/60/28 | 0.323 | 8 |
| −572C/G [rs1800797] | ||||||||
| Chou, 2016 | Adult | Taiwan | Asian | 279/156 | 184/62/33 | 106/32/18 | 0.000 | 8 |
| Su, 2019 | Pediatric | China | Asian | 438/423 | 206/193/39 | 351/58/14 | 0.000 | 8 |
| First Author, Year | Age group | Country | Ethnicity | Sample Size (Severe/Non-severe) | Genotype (GG/GC/CC) |
p value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|
| Severe | Non-severe | |||||||
| −174 G/C [rs1800795] | ||||||||
| Mao, 2016 | Adult | China | Asian | 188/200 | 56/37/95 | 68/46/48 | 0.000 | 8 |
| Schaaf, 2005 | Adult | Germany | Caucasian | 25/75 | 3/15/7 | 26/36/13 | 0.929 | 8 |
| Sole-Violan, 2010 [a] | Adult | Spain | Caucasian | 159/817 | 73/68/18 | 392/341/84 | 0.441 | 8 |
| Sole-Violan, 2010 [b] | Adult | Spain | Caucasian | 162/817 | 68/76/18 | 392/341/84 | 0.441 | 8 |
| Sole-Violan, 2010 [c] | Adult | Spain | Caucasian | 137/1001 | 59/62/16 | 474/423/104 | 0.504 | 8 |
Bold values indicate the results were deviated from HWE (Hardy–Weinberg equilibrium); mt, mutant type; wt, wild type.