Figure 2.

Effects of repeated gavage administration of clavulanic acid (CLAV: 10, 20, 40, and 80 mg/kg) on A: Percent of number of entries to the open arm/total entries and B: Percent of time spent in the open arm/total time in the elevated plus maze (EPM) in rats following withdrawal from repeated administration of ethanol (10% v/v, 2 g/kg), twice a day for 10 days. Values are means ±SEM. (n=8). Naïve (distilled water + orange juice) versus control ethanol group: # P<0.05, ### P<0.001. Statistical significant differences compared with ethanol controls are indicated by * P<0.05, ** P<0.01, and *** P<0.001. Tukey’s post hoc test, following one-way ANOVA, was used. Dz (diazepam, 3 mg/kg, via gavage) is the positive control group