Figure 3.

Effects of repeated gavage administration of clavulanic acid (CLAV: 10, 20, 40, and 80 mg/kg) on the susceptibility induced by sub-convulsive dose of penthyltetrazole (PTZ, 20 mg/kg, IP), following withdrawal from repeated administration of ethanol (10% v/v, 2 g/kg), twice a day for 10 days. Stage 1: ear and facial twitching; Stage 2: myoclonic jerks without rearing; Stage 3: myoclonic jerks and rearing; Stage 4: over into side position, tonic-clonic seizure. Values are means ±SEM for (n=8). Significant differences by Fisher’s exact test was used: Naïve versus control ethanol group: ### P<0.001. ** P<0.01, *** P<0.001, compared with ethanol. Dz (diazepam, 3 mg/kg, via gavage) is the positive control group