TABLE 2.
Baseline demographics and hippocampal and entorhinal cortex volume.
| Variables at baseline (mean ± SD) |
Diagnosis group |
P-value | |||
| NC (n = 194) | MCI (n = 200) | MCI_c (n = 84) | AD (n = 130) | ||
| Sex (M/F) | 96/98 | 127/73 | 49/35 | 60/70 | 0.003 |
| Age | 76.17 (5.20) | 74.74 (7.18) | 74.88 (7.30) | 76.01 (7.35) | 0.111 |
| MMSE score | 29 (1.0) | 27 (1.82) | 26 (1.84) | 23 (2.16) | <0.001 |
| CDR | 0.0 (0.00) | 0.50 (0.04) | 0.50 (0.00) | 0.75 (0.25) | <0.001 |
| Entorhinal cortex volume (mm3) | 1,930 (284) | 17,191,723 (384) | 154,410 (338) | 1,417 (348) | <0.001 |
| Hippocampal volume (mm3) | 3,539 (413) | 3,243 (461) | 2,941 (461) | 2,892 (474) | <0.001 |
NC, normal controls; MCI, mild cognitive impairment; MCIc, mild cognitive impairment converter; AD, Alzheimer’s disease; MMSE, mini-mental status examination; CDR, clinical dementia rating; SD, standard deviation.