TABLE 3.
Mean differences at baseline scans for entorhinal cortex and hippocampus.
|
Mean difference (SE) |
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|
Entorhinal cortex |
Hippocampus |
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| Group | NC vs. AD | NC vs. MCI | MCI vs. MCIc | MCI vs. AD | NC vs. AD | NC vs. MCI | MCI vs. MCIc | MCI vs. AD |
| Texture features | ||||||||
| ASM | −0.017*(0.005) | −0.01(0.004) | −0.007(0.006) | −0.006(0.005) | −0.013*(0.004) | −0.008(0.004) | −0.023*(0.005) | −0.023*(0.005) |
| Contrast | −024.3*(2.60) | −7.73*(2.27) | −7.36(2.93) | −16.60*(2.60) | −2.0(2.36) | −3.61(2.11) | −4.62(2.70) | −5.60(2.32) |
| Correlation | −0.051*(0.005) | −0.017*(0.004) | −0.013(0.005) | −0.034*(0.005) | −0.0004(0.005) | −0.0004(0.005) | −0.016(0.007) | −0.001(0.005) |
| Variance | −0.201(1.14) | −1.11(1.01) | −0.780(1.30) | −0.910(1.14) | −2.40(2.80) | −4.90(2.46) | −13.0*(2.20) | −7.30(2.77) |
| Sum average | −1.44*(0.365) | −0.590(0.324) | −0.821(0.414) | −0.853(0.361) | −1.64*(0.560) | −0.823(0.498) | 2.40*(0.640) | −2.47*(0.556) |
| Sum variance | −27.70*(4.15) | −12.28*(3.68) | −2.18(4.80) | −15.41*(4.14) | −6.30(10.0) | −15.20(8.80) | −41.0*(11.3) | −21.5(9.80) |
| Entropy | −0.137*(0.023) | −0.058*(0.020) | −0.060(0.026) | −0.080*(0.023) | −0.103*(0.028) | −0.034(0.024) | −0.113*(0.030) | −0.138*(0.026) |
| Cluster shade | −471(350) | −260(312) | −118*(414) | −730(342) | −1,009(1,038) | −2,373(927) | −4,600*(1182) | −3,383(1,026) |
| Volumetric features | ||||||||
| Volume | −513*(39.1) | −211*(34.8) | −174*(45.0) | −301*(38.7) | −646*(52.4) | −295*(42.7) | −302*(60.0) | −351*(51) |
SE, standard error; ASM, angular second moment; NC, normal controls; MCI, mild cognitive impairment; MCIc, mild cognitive impairment converter; AD, Alzheimer’s disease. *The mean difference is significant at the 0.05 level.