TABLE 4.

Entorhinal cortex texture and volume in classifying NC vs. AD.

NC vs. AD	ROC analysis AUC	95% CI	P-value
Entorhinal cortex
Texture features
ASM	0.592	0.529–0.656	0.005
Contrast	0.794	0.743–0.845	<0.001
Correlation	0.824	0.776–0.872	<0.001
Variance	0.524	0.458–0.590	0.475
Sum average	0.620	0.555–0.681	<0.001
Sum variance	0.713	0.653–0.770	<0.001
Entropy	0.685	0.625–0.744	<0.001
Cluster shade	0.540	0.475–0.604	0.238
Volume and thickness
Erc. volume	0.888	0.847–0.925	<0.001
Erc. thickness	0.809	0.755–0.863	<0.001
Features combination
Texture (ASM, correlation, variance, sum average, and cluster shade)	0.872	0.828–0.916	<0.001
Texture + Erc. volume	0.914	0.879–0.950	<0.001
Hippocampus
Hippocampal volume	0.869	0.827–0.912	<0.001

NC, Normal Controls; AD, Alzheimer’s disease; ROC, receiver operating characteristic; AUC, area under curve, CI, confidence interval; ASM, angular second moment; Erc, entorhinal cortex.