TABLE 5.

Entorhinal cortex texture and volume in classifying NC vs. MCI.

NC vs. MCI	ROC analysis AUC	95% CI	P-value
Entorhinal cortex
Texture features
ASM	0.618	0.563–0.674	<0.001
Contrast	0.664	0.611–0.718	<0.001
Correlation	0.671	0.617–0.725	<0.001
Variance	0.604	0.548–0.660	<0.001
Sum average	0.618	0.562–0.674	<0.001
Sum Variance	0.641	0.586–0.695	<0.001
Entropy	0.632	0.577–0.687	<0.001
Cluster shade	0.608	0.551–0.666	<0.001
Volumetric and thickness
Erc. volume	0.735	0.686–0.784	<0.001
Erc. thickness	0.659	0.604–0.713	<0.001
Features combination
Texture (ASM, correlation, variance, sum average, and cluster shade)	0.710	0.656–0.762	<0.001
Texture and Erc. volume	0.740	0.689–0.791	<0.001
Hippocampus
Hippocampal volume	0.762	0.715–0.809	<0.001

NC, normal controls; MCI, mild cognitive impairment; ROC, receiver operating characteristic; AUC, area under curve, CI, confidence interval; ASM, angular second moment; Erc, entorhinal cortex.