TABLE 7.

Entorhinal cortex texture and volume in classifying MCI vs. AD.

MCI vs. AD	ROC analysis AUC	95% CI	P-value
Entorhinal cortex
Texture features
ASM	0.627	0.565–0.690	<0.001
Contrast	0.704	0.646–0.763	<0.001
Correlation	0.725	0.668–0.783	<0.001
Variance	0.624	0.560–0.688	<0.001
Sum average	0.649	0.587–0.711	<0.001
Sum variance	0.658	0.596–0.720	<0.001
Entropy	0.656	0.594–0.718	<0.001
Cluster shade	0.645	0.583–0.706	<0.001
Volume and thickness
Erc. volume	0.726	0.670–0.781	<0.001
Erc. thickness	0.702	0.642–0.762	<0.001
Features combination
Texture (ASM, correlation, variance, sum average, and cluster shade)	0.764	0.710–0.818	<0.001
Texture + Erc. volume	0.780	0.728–0.833	<0.001
Hippocampus
Hippocampal volume	0.711	0.652–0.771	<0.001

MCI, mild cognitive impairment; AD, Alzheimer’s disease; ROC, receiver operating characteristic; AUC, area under curve, CI, confidence interval; ASM, angular second moment; Erc, entorhinal cortex.