TABLE 8.

Statistically significant difference in entorhinal cortex and hippocampal volume over an 18-month intervention.

Within-subjects effects	Entorhinal cortex volume Mean (SD) mm3		Hippocampal volume Mean (SD) mm3
	MCI	MCIc	MCI	MCIc
Baseline	1,733 (390)	1,504 (293)	3,263 (483)	2,906 (439)
6 months	1,712 (389)	1,449 (278)	3,213 (487)	2,860 (423)
12 months	1,693 (393)	1,424 (269)	3,168 (496)	2,819 (432)
18 months	1,657 (411)	1,384 (269)	3,129 (487)	2,781 (436)
F-ratio (Time)	F(2.837, 383) = 45.62, P < 0.0005	F(3, 186) = 45.06, P < 0.0005	F(2.748, 376) = 41.8, P < 0.0005	F(3, 195) = 21.74, P < 0.0005

MCI, mild cognitive impairment; MCIc, mild cognitive impairment converters; SD, standard deviation.