TABLE 9.

Statistically significant difference in entorhinal cortex texture over an 18-month intervention.

	Entorhinal cortex texture features – mean (SD)
	ASM	Contrast	Correlation	Sum variance	Variance	Sum variance	Entropy	Cluster shade
MCI stable
Baseline	0.226 (0.047)	220 (22.38)	0.498 (0.043)	659.4 (38.0)	220 (9.49)	659 (38.0)	2.92 (0.216)	1,838 (3,218)
6 months	0.228 (0.046)	223 (20.95)	0.495 (0.041)	659.2 (38.5)	221 (9.90)	659 (38.5)	2.90 (0.221)	1,198 (,2986)
12 months	0.230 (0.047)	223 (19.34)	0.494 (0.043)	656.0 (38.1)	220 (9.50)	655 (41.9)	2.89 (0.212)	1,276 (3,086)
18 months	0.234 (0.047)	222 (24.71)	0.493 (0.049)	654.0 (38.1)	219 (10.7)	654 (44.3)	2.89 (0.212)	1,300 (2,989)
F-ratio (Time)	F(3, 417) = 2.45 P = 0.620	F(3, 384) = 1.05 P = 0.370	F(3, 375) = 1.14 P = 0.332	F(3, 411) = 2.17 P = 0.09	F(3, 411) = 1.44 P = 0.230	F(3, 411) = 2.17 P = 0.091	F(3, 414) = 2.65 P = 0.048	F(3, 396) = 2.49 P = 0.060
MCI converters
Baseline	0.230 (0.041)	230 (26.6)	0.480 (0.046)	655.4 (35.0)	221 (10.5)	655 (35.0)	2.87 (0.179)	-296.7 (1,860)
6 months	0.237 (0.039)	238 (27.4)	0.468 (0.043)	650.0 (40.5)	222 (11.4)	650 (40.5)	2.82 (0.185)	-388.4 (2,363)
12 months	0.235 (0.040)	237 (28.5)	0.468 (0.047)	647.4 (42.0)	222 (12.0)	637 (42.0)	2.82 (0.186)	-385.0 (2,394)
18 months	0.243 (0.043)	238 (28.8)	0.459 (0.047)	637.8 (44.3)	219 (12.7)	647 (44.3)	2.79 (0.156)	-557.1 (2,032)
F-ratio (Time)	F(2.72, 179.5) = 3.86 P = 0.013	F(3, 201) = 5.80 P < 0.0005	F(3, 192) = 6.82 P < 0.0005	F(3, 201) = 7.45 P < 0.0005	F(3, 198) = 3.55 P < 0.0005	F(3, 201) = 7.45 P < 0.0005	F(3, 204) = 7.30 P < 0.0005	F(3, 162) = 0.23 P = 0.874

MCI, mild cognitive impairment; ASM, angular second moment; SD, standard deviation.