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. 2020 Jul 2;11:888. doi: 10.3389/fphar.2020.00888

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Copyright © 2020 Shukla, Goswami, Keizer, Winger, Kharbanda, Dvorak and Long-Boyle

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the ratio of observed AUC verses goal exposure for the three cohorts. (A) The ratio of busulfan 1st dose PK observed to the pre-defined AUC target. (B) The ratio of busulfan cAUC observed to the pre-defined cAUC target.