Table 2.
Comparison of the ratio of observed verses pre-defined goal AUC for 1st PK assessment and overall cAUC.
| Cohort A | Cohort B | Cohort C | |
|---|---|---|---|
| 1st PK Assessment | |||
| Ratio of AUCobs/AUCtarget
Median (range) |
0.64 (0.38–1.1) |
0.85 (0.39–2.1) |
0.93 (0.51–1.8) |
| Coefficient of variation (%CV) | 28% | 31% | 24% |
| Number of subjects | 53 | 74 | 57 |
| Overall cAUC | |||
| Ratio cAUCobs/cAUCtarget
Median (range) |
1.10 (0.74–1.5) |
1.00 (0.66–2.1) |
1.00 (0.88–1.10) |
| Coefficient of variation (%CV) | 15% | 17% | 4% |
| Number of subjects | 53 | 76 | 59 |
Data expressed as median (range). AUCobs, area under the curve observed; AUCtarget, area under the curve target; cAUCobs, cumulative area under the curve observed; cAUCtarget, cumulative area under the curve target; CV, coefficient of variation.