Table 4.

Natural components with potential to bind the 2019-nCoV receptor, ACE2.

Components	ΔG (kcal/mol)	Sites	IC50 (μg/ml)	CC50 (μg/ml)	References
Scutellarin	−14.9	495E, 957X, 482R	NM	NM	Chen and Du, 2020
Glycyrrhizin	−9.0	559R, 388Q, 393R, 30D	NM	>20000	Chen and Du, 2020
Baicalin	−8.46	149N,273R, 505H	NM	>100	Chen and Du, 2020
Hesperetin	−8.3	613Y, 611S, 482R, 479E	NM	820 ± 15	Chen and Du, 2020
Naringin	−6.85	515Y, 402E, 398E, 394N	NM	2,000	Cheng et al., 2020
Hesperetin	−6.09	562K, 564E, 205G	NM	820 ± 15	Cheng et al., 2020
Naringenin	−6.05	146P, 143L, 131K	NM	NM	Cheng et al., 2020
Nobiletin	−5.42	69W, 351L, 350D	NM	NM	Cheng et al., 2020
Nicotianamine	−5.1	518R, 406E, 409S, 522Q, 442Q	25.5	NM	Chen and Du, 2020
Hesperidin	−4.21	277N, 273R, 505H	NM	NM	Cheng et al., 2020
Neohesperidin	−3.78	349W, 348A, 69W	NM	NM	Cheng et al., 2020