Table 3.
Sensitivity (Se) and specificity (Sp) of diagnostic tests.
| Diagnostic test | TB positive (farm A) | Unvaccinated (farm B) | BCG vaccinated (farm C) | |||
|---|---|---|---|---|---|---|
| N9 | Se (95% CI)10 | N | Sp (95% CI11 | N | Sp (95% CI)11 | |
| sP22-ST1 | 77 | 87% (77–94) | 77 | 92% (84–97) | 61 | 97% (89–100) |
| cP22-ST2 | 77 | 74% (63–83) | 77 | 100% (95–100) | 61 | 98% (91–100) |
| SIT3 | 77 | 94% (85–98) | 77 | 94% (85–98) | 61 | 67% (54–79) |
| SICCT4 | 77 | 91% (82–96) | 77 | 100% (95–100) | 61 | 80% (68–89) |
| sP22-IGRA5 | 77 | 91% (82–96) | 74 | 95% (87–99) | 68 | 84% (73–92) |
| cP22-IGRA6 | 77 | 86% (76–93) | 74 | 96% (89–99) | 68 | 85% (75–93) |
| STAND-IGRA7 | 77 | 77% (66–86) | 74 | 100% (95–100) | 68 | 96% (88–99) |
| DIVA-IGRA8 | 77 | 71% (60–81) | 74 | 100% (95–100) | 68 | 100% (95–100) |
| P22-ELISA | 77 | 74% (63–83) | 74 | 93% (85–98) | 68 | 96% (88–99) |
| MPB83-ELISA | 77 | 75% (64–84) | 74 | 92% (83–97) | 68 | 94% (86–98) |
1
sP22-ST, single P22 skin test;
2
cP22-ST, comparative P22 skin test;
3
SIT, single intradermal tuberculin test;
4
SICCT, single intradermal cervical comparative tuberculin test;
5
sP22-IGRA, single P22 IGRA test;
6
cP22-IGRA, comparative P22 IGRA test;
7
STAND-IGRA, standard tuberculin IGRA test;
8
DIVA-IGRA, differentiating Infected from Vaccinated animals (ESAT-6/CFP-10 peptide cocktail) IGRA test.
9
Number of animals tested.
10
Clopper–Pearson 95% confidence interval for Se.
11
Clopper–Pearson 95% confidence interval for Sp.
TB, tuberculosis; BCG, bacille Calmette-Guérin; IGRA, interferon-gamma release assay.