Table 4.
Sensitivity (Se) and specificity (Sp) combined results of P22-based diagnostic tests.
| Diagnostic tests | TB positive (farm A) | Unvaccinated (farm B) | BCG vaccinated (farm C) | |||
|---|---|---|---|---|---|---|
| N8 | Se (95% CI)9 | N | Sp (95% CI)10 | N | Sp (95% CI)10 | |
| SIT1 + sP22-IGRA2 | 77 | 97% (91–100) | 73 | 89% (80–95) | 61 | 59% (46–71) |
| SIT + cP22-IGRA3 | 77 | 97% (91–100) | 73 | 90% (81–96) | 61 | 61% (47–73) |
| SIT + P22-ELISA | 77 | 96% (89–99) | 73 | 89% (80–95) | 61 | 66% (52–77) |
| SICCT4 + sP22-IGRA | 77 | 97% (91–100) | 73 | 95% (87–98) | 61 | 67% (54–79) |
| SICCT + cP22-IGRA | 77 | 97% (91–100) | 73 | 96% (88–99) | 61 | 67% (54–79) |
| SICCT + P22-ELISA | 77 | 95% (87–99) | 73 | 95% (87–98) | 61 | 79% (66–88) |
| sP22-ST5 + sP22-IGRA | 77 | 95% (87–99) | 73 | 88% (78–94) | 61 | 82% (70–91) |
| sP22-ST + P22-ELISA | 77 | 94% (85–98) | 73 | 88% (78–94) | 61 | 93% (84–98) |
| cP22-ST6 + sP22-IGRA | 77 | 95% (87–99) | 73 | 95% (87–98) | 61 | 84% (72–92) |
| cP22-ST + P22-ELISA | 77 | 94% (85–98) | 73 | 95% (87–98) | 61 | 95% (86–99) |
| sP22-IGRA + STAND-IGRA7 | 77 | 92% (84–97) | 74 | 95% (87–99) | 68 | 84% (73–92) |
| P22-ELISA + sP22-IGRA | 77 | 95% (87–99) | 74 | 89% (80–95) | 68 | 79% (68–88) |
| P22 ELISA + cP22-IGRA | 77 | 95% (87–99) | 74 | 91% (81–96) | 68 | 81% (70–89) |
| P22-ELISA + MPB83-ELISA | 77 | 87% (77–94) | 74 | 92% (83–97) | 68 | 90% (80–96) |
| P22-ELISA + STAND-IGRA | 77 | 90% (81–95) | 74 | 93% (85–98) | 68 | 91% (82–97) |
| SIT + STAND-IGRA | 77 | 95% (87–99) | 73 | 93% (85–98) | 61 | 67% (54–79) |
| SICCT + STAND-IGRA | 77 | 95% (87–99) | 73 | 100% (95–100) | 61 | 80% (68–89) |
1
SIT, single intradermal tuberculin test;
2
sP22-IGRA, single P22 IGRA test;
3
cP22-IGRA, comparative P22 IGRA test;
4
SICCT, single intradermal cervical comparative intradermal tuberculin test;
5
sP22-ST, single P22 skin test;
6
cP22-ST, comparative P22 skin test;
7
STAND-IGRA, standard tuberculin IGRA test.
8
Number of animals tested;
9
Clopper–Pearson 95% confidence interval for Se.
10
Clopper–Pearson 95% confidence interval for Sp.
TB, tuberculosis; BCG, bacille Calmette-Guérin; IGRA, interferon-gamma release assay.