Table 3.
Standardized incidence rate ratios (SIRs) with 95% confidence intervals (CIs) and absolute reduction in dementia risk attributed to cancer per 10,000 person-years for any dementia, in 679,122 Danish cancer patients with specific cancer sites diagnosed between 1980 and 2013, by stage.
| Alzheimer’s disease | Vascular dementia | All-cause dementia | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Observed number | Expected number | SIR (95% CI) | Absolute risk reduction | Observed number | Expected number | SIR (95% CI) | Absolute risk reduction | Observed number | Expected number | SIR (95% CI) | Absolute risk reduction | |
| Bladder cancer | 227 | 242 | 0.94 (0.82, 1.07) | 1.6 | 98 | 97 | 1.01 (0.82, 1.23) | −0.1 | 640 | 662 | 0.97 (0.89, 1.04) | 2.3 |
| Localized | 135 | 148 | 0.91 (0.77, 1.08) | 2.1 | 59 | 60 | 0.99 (0.75, 1.28) | 0.1 | 385 | 403 | 0.96 (0.86, 1.06) | 3.0 |
| Regional | 28 | 23 | 1.23 (0.81, 1.77) | −5.2 | 17 | 9 | 1.90 (1.11, 3.05) | −8.1 | 67 | 60 | 1.11 (0.86, 1.41) | −6.8 |
| Distant | <5 | 3 | NA | 12.9 | <5 | 1 | NA | 7.6 | 8 | 7 | 1.08 (0.47, 2.13) | −3.9 |
| Missing/Unknown | 63 | 69 | 0.92 (0.70, 1.17) | 2.5 | 22 | 28 | 0.79 (0.50, 1.20) | 2.5 | 180 | 192 | 0.94 (0.81, 1.09) | 5.0 |
| Brain cancer | 13 | 8 | 1.62 (0.86, 2.77) | −1.6 | 10 | 3 | 2.90 (1.39, 5.33) | −2.1 | 91 | 24 | 3.77 (3.03, 4.63) | −21.1 |
| Breast cancer | 1495 | 1569 | 0.95 (0.91, 1.00) | 0.8 | 486 | 492 | 0.99 (0.90, 1.08) | 0.1 | 4129 | 4132 | 1.00 (0.97, 1.03) | 0.0 |
| Localized | 899 | 901 | 1.00 (0.93, 1.07) | 0.0 | 276 | 285 | 0.97 (0.86, 1.09) | 0.2 | 2403 | 2385 | 1.01 (0.97, 1.05) | −0.4 |
| Regional | 419 | 471 | 0.89 (0.81, 0.98) | 1.7 | 148 | 147 | 1.01 (0.85, 1.18) | 0.0 | 1176 | 1214 | 0.97 (0.91, 1.03) | 1.2 |
| Distant | 30 | 38 | 0.79 (0.53, 1.12) | 4.3 | 10 | 11 | 0.90 (0.43, 1.66) | 0.6 | 94 | 95 | 0.99 (0.80, 1.21) | 0.4 |
| Missing/unknown | 147 | 158 | 0.93 (0.78, 1.09) | 1.9 | 52 | 50 | 1.05 (0.78, 1.37) | −0.4 | 456 | 438 | 1.04 (0.95, 1.14) | −3.0 |
| Colon cancer | 833 | 944 | 0.88 (0.82, 0.94) | 3.6 | 279 | 337 | 0.83 (0.73, 0.93) | 1.9 | 2343 | 2598 | 0.90 (0.87, 0.94) | 8.4 |
| Localized | 207 | 253 | 0.82 (0.71, 0.94) | 6.0 | 71 | 86 | 0.83 (0.64, 1.04) | 1.9 | 585 | 668 | 0.88 (0.81, 0.95) | 10.8 |
| Regional | 93 | 104 | 0.90 (0.73, 1.10) | 3.0 | 22 | 34 | 0.64 (0.40, 0.98) | 3.4 | 231 | 266 | 0.87 (0.76, 0.99) | 9.9 |
| Distant | 20 | 27 | 0.75 (0.46, 1.16) | 5.8 | <5 | 8 | NA | 4.8 | 54 | 64 | 0.85 (0.64, 1.11) | 8.3 |
| Missing/unknown | 513 | 561 | 0.91 (0.84, 1.00) | 2.6 | 183 | 208 | 0.88 (0.76, 1.02) | 1.4 | 1473 | 1601 | 0.92 (0.87, 0.97) | 7.0 |
| Kidney cancer | 86 | 110 | 0.78 (0.62, 0.96) | 3.7 | 53 | 42 | 1.25 (0.94, 1.63) | −1.6 | 286 | 303 | 0.95 (0.84, 1.06) | 2.5 |
| Localized | 62 | 74 | 0.84 (0.65, 1.08) | 2.6 | 43 | 29 | 1.48 (1.07, 2.00) | −3.1 | 204 | 206 | 0.99 (0.86, 1.14) | 0.4 |
| Regional | 5 | 9 | 0.56 (0.18, 1.30) | 8.1 | <5 | 3 | NA | NA | 17 | 24 | 0.72 (0.42, 1.15) | 13.4 |
| Distant | 6 | 7 | 0.86 (0.31, 1.86) | 2.0 | <5 | 3 | NA | NA | 16 | 18 | 0.88 (0.50, 1.43) | 4.2 |
| Missing/unknown | 13 | 21 | 0.63 (0.33, 1.08) | 7.6 | 8 | 8 | 1.06 (0.46, 2.08) | −0.4 | 49 | 55 | 0.89 (0.66, 1.18) | 6.0 |
| Leukemia | 150 | 162 | 0.93 (0.78, 1.09) | 1.2 | 51 | 60 | 0.85 (0.63, 1.11) | 0.9 | 395 | 440 | 0.90 (0.81, 0.99) | 4.5 |
| Lung cancer | 174 | 207 | 0.84 (0.72, 0.97) | 2.5 | 65 | 81 | 0.80 (0.62, 1.02) | 1.2 | 613 | 546 | 1.12 (1.04, 1.22) | −5.1 |
| Localized | 83 | 101 | 0.82 (0.66, 1.02) | 2.9 | 38 | 41 | 0.93 (0.66, 1.28) | 0.5 | 291 | 272 | 1.07 (0.95, 1.20) | −3.0 |
| Regional | 32 | 43 | 0.75 (0.51, 1.06) | 3.2 | 12 | 18 | 0.68 (0.35, 1.19) | 1.7 | 124 | 115 | 1.07 (0.89, 1.28) | −2.6 |
| Distant | 25 | 38 | 0.67 (0.43, 0.98) | 5.4 | 8 | 14 | 0.58 (0.25, 1.14) | 2.5 | 110 | 97 | 1.14 (0.93, 1.37) | −5.6 |
| Missing/unknown | 34 | 26 | 1.31 (0.91, 1.83) | −6.5 | 7 | 9 | 0.82 (0.33, 1.68) | 1.3 | 88 | 61 | 1.43 (1.15, 1.76) | −21.6 |
| Melanoma skin cancer | 284 | 325 | 0.87 (0.78, 0.98) | 1.5 | 92 | 124 | 0.74 (0.60, 0.91) | 1.2 | 805 | 929 | 0.87 (0.81, 0.93) | 4.5 |
| Localized | 253 | 285 | 0.89 (0.78, 1.00) | 1.3 | 82 | 110 | 0.75 (0.59, 0.93) | 1.1 | 715 | 820 | 0.87 (0.81, 0.94) | 4.2 |
| Regional | 9 | 10 | 0.94 (0.43, 1.78) | 0.7 | <5 | 4 | NA | NA | 27 | 27 | 1.01 (0.66, 1.47) | −0.3 |
| Distant | <5 | 2.8 | NA | NA | <5 | 1 | NA | NA | <5 | 7 | NA | NA |
| Missing/unknown | 20 | 27 | 0.73 (0.44, 1.12) | 3.9 | 9 | 10 | 0.91 (0.42, 1.74) | 0.4 | 59 | 76 | 0.78 (0.59, 1.00) | 8.9 |
| Non-melanoma skin cancer | 3876 | 4005 | 0.97 (0.94, 1.00) | 0.8 | 1366 | 1505 | 0.91 (0.86, 0.96) | 0.9 | 10805 | 11479 | 0.94 (0.92, 0.96) | 4.3 |
| Localized | 3316 | 3384 | 0.98 (0.95, 1.01) | 0.5 | 1171 | 1277 | 0.92 (0.87, 0.97) | 0.8 | 9251 | 9725 | 0.95 (0.93, 0.97) | 3.6 |
| Regional | 16 | 11 | 1.50 (0.86, 2.43) | −15.3 | <5 | 4 | NA | NA | 36 | 31 | 1.17 (0.82, 1.63) | −15.3 |
| Distant | 5 | 2 | 2.48 (0.80, 5.77) | −35.6 | <5 | 1 | NA | NA | 9 | 6 | 1.60 (0.74, 3.05) | −40.5 |
| Missing/unknown | 539 | 608 | 0.89 (0.81, 0.96) | 2.8 | 190 | 223 | 0.85 (0.74, 0.98) | 1.3 | 1509 | 1718 | 0.88 (0.83, 0.92) | 8.5 |
| Pancreatic cancer | 19 | 26 | 0.72 (0.43, 1.13) | 5.2 | 4 | 9 | 0.45 (0.12, 1.15) | 3.5 | 59 | 66 | 0.90 (0.69, 1.16) | 4.7 |
| Localized | 8 | 7 | 1.19 (0.51, 2.34) | −3.4 | <5 | 2 | NA | NA | 17 | 17 | 1.00 (0.58, 1.60) | 0.1 |
| Regional | <5 | 6 | NA | NA | <5 | 2 | NA | NA | 10 | 14 | 0.70 (0.34, 1.29) | 10.8 |
| Distant | <5 | 5 | NA | NA | <5 | 2 | NA | NA | 14 | 11 | 1.22 (0.67, 2.05) | −8.3 |
| Missing/unknown | 6 | 9 | 0.67 (0.25, 1.46) | 9.0 | 2 | 3 | 0.66 (0.08, 2.39) | 3.2 | 18 | 23 | 0.79 (0.47, 1.25) | 14.9 |
| Prostate cancer | 779 | 813 | 0.96 (0.89, 1.03) | 1.2 | 325 | 340 | 0.96 (0.85, 1.07) | 0.5 | 2175 | 2237 | 0.97 (0.93, 1.01) | 2.2 |
| Localized | 387 | 399 | 0.97 (0.88, 1.07) | 0.8 | 162 | 164 | 0.99 (0.84, 1.15) | 0.1 | 1080 | 1077 | 1.00 (0.94, 1.06) | −0.2 |
| Regional | 29 | 27 | 1.09 (0.73, 1.57) | −2.1 | 10 | 11 | 0.91 (0.43, 1.67) | 0.9 | 69 | 70 | 0.98 (0.76, 1.24) | 1.2 |
| Distant | 84 | 94 | 0.90 (0.72, 1.11) | 3.1 | 22 | 40 | 0.55 (0.35, 0.83) | 5.7 | 217 | 258 | 0.84 (0.73, 0.96) | 13.0 |
| Missing/unknown | 279 | 294 | 0.95 (0.84, 1.07) | 1.8 | 131 | 125 | 1.05 (0.88, 1.24) | −0.7 | 809 | 831 | 0.97 (0.91, 1.04) | 2.5 |