Table 1. Analysis of the Association Between SLC30A8 SNP rs13266634 ‘T’ allele with Disease Phenotypes Using Electronic Health Record (EHR)-Derived Analyses.

Data show an association between SLC30A8 SNP rs13266634 and various diabetes and hemolytic anemia sub-groups in the total EHR population and in the European American (EA) population within the EHR. No associations were observed in the African American (AA) population or separately in the EA population or AA population when split into with- or without-T2D sub-groups (data not shown). ‘Phecodes’ refer to the numerical abbreviation for individual phenotypes in the VUMC-EHR. All associations were adjusted for the covariates median age of record, sex, and EHR-reported race, and the top 4 principal ancestry components using linear regression. SE, standard error; OR, odds ratio; FDR, false discovery rate; LCI, lower confidence interval; UCI, upper confidence interval.

Population	Phecode	Description	Beta	SE	OR	P	N Total	N Cases	N Controls	LCI	UCI	Bonferroni	FDR
Total	250.1	Type 1 diabetes	−0.11	0.02	0.90	3.60E–06	31084	2041	29043	0.85	0.94	TRUE	TRUE
Total	250.2	Type 2 diabetes	−0.06	0.01	0.94	1.04E–05	36594	7551	29043	0.92	0.97	TRUE	TRUE
Total	250.23	Type 2 diabetes with ophthalmic manifestations	−0.18	0.04	0.84	4.00E–05	29673	630	29043	0.77	0.91	TRUE	TRUE
Total	250.22	Type 2 diabetes with renal manifestations	−0.12	0.03	0.89	1.34E–04	30285	1242	29043	0.84	0.94	FALSE	TRUE
Total	282.9	Other hereditary hemolytic anemias	−0.33	0.09	0.72	1.71E–04	26615	227	26388	0.60	0.85	FALSE	TRUE
Total	282	Hereditary hemolytic anemias	−0.24	0.07	0.78	2.26E–04	26757	369	26388	0.69	0.89	FALSE	TRUE
All EA	250.1	Type 1 diabetes	−0.11	0.03	0.89	1.01E–05	25267	1701	23566	0.85	0.94	TRUE	TRUE
All EA	250.2	Type 2 diabetes	−0.06	0.01	0.94	2.95E–05	30041	6475	23566	0.91	0.97	TRUE	TRUE
All EA	250	Diabetes mellitus	−0.05	0.01	0.95	1.13E–04	30390	6824	23566	0.92	0.97	FALSE	TRUE