Table 2. Analysis of the Association Between SLC30A8 SNP rs13266634 ‘T’ allele with Laboratory Analytes Using Electronic Health Record (EHR)-Derived Analyses.

Data show an association between SLC30A8 SNP rs13266634 and blood glucose, mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), glycated hemoglobin A1c and total blood protein in the total EHR population. Some of these associations are maintained in the European American (EA) population and the EA sub-population without T2D within the EHR. No associations were observed in the African American (AA) population or in EAs with T2D (data not shown). SE, standard error; OR, odds ratio; FDR, false discovery rate; LCI, lower confidence interval; UCI, upper confidence interval. For each laboratory value, we tested for associations between the median of all lab values for an individual against the number of minor alleles for that individual. All associations were adjusted for covariates median age of record, sex, and EHR-reported race, and the top four principal ancestry components using linear regression. The units for all measurements in any given lab were consistent within the lab (e.g. all blood glucose values were reported in mg/dL).

Population	Analyte	Effect Estimate	SE	OR	P	N	LCI	UCI	Bonferroni	FDR
Total	GLUCOSE BLOOD	−0.03	0.005	0.97	3.02E–10	40908	0.96	0.98	TRUE	TRUE
Total	MEAN CORPUSCULAR HEMOGLOBIN (MCH)	0.03	0.005	1.03	4.95E–08	41776	1.02	1.04	TRUE	TRUE
Total	MEAN CORPUSCULAR VOLUME (MCV)	0.02	0.005	1.03	1.80E–07	41772	1.02	1.03	TRUE	TRUE
Total	HGB A1C GLYCATED	−0.04	0.008	0.96	1.01E–06	15428	0.95	0.98	TRUE	TRUE
Total	PROTEIN TOTAL BLOOD	−0.02	0.005	0.98	4.78E–06	33870	0.97	0.99	TRUE	TRUE
All EA	GLUCOSE BLOOD	−0.03	0.005	0.97	1.97E–11	34244	0.96	0.98	TRUE	TRUE
All EA	HGB A1C GLYCATED	−0.03	0.008	0.97	1.11E–04	12996	0.95	0.98	FALSE	TRUE
Non T2D EA	GLUCOSE BLOOD	−0.02	0.005	0.98	4.52E–05	22654	0.97	0.99	TRUE	TRUE